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| 1 | Transformers | $70,502,384 | 4,011 | $17,577 | $155,405,412 | -- | 1 | Paramount |
| 2 | Ratatouille | $29,014,293 | 3,940 | $7,364 | $109,531,598 | -38.3 | 2 | Buena Vista |
| 3 | Live Free or Die Hard | $17,730,149 | 3,411 | $5,198 | $84,424,123 | -46.9 | 2 | Fox |
| 4 | License to Wed | $10,422,258 | 2,604 | $4,002 | $17,838,076 | -- | 1 | Warner Bros. |
| 5 | Evan Almighty | $8,719,135 | 3,460 | $2,520 | $78,706,785 | -42.4 | 3 | Universal |
| 6 | 1408 | $7,088,979 | 2,631 | $2,694 | $53,738,325 | -33.5 | 3 | MGM |
| 7 | Knocked Up | $5,222,680 | 2,213 | $2,360 | $132,089,425 | -28.5 | 6 | Universal |
| 8 | Fantastic Four: Rise of the SS | $4,239,993 | 2,618 | $1,620 | $123,881,586 | -53.6 | 4 | Fox |
| 9 | Sicko | $3,600,179 | 702 | $5,128 | $11,452,560 | -20.0 | 3 | Lionsgate |
| 10 | Ocean's Thirteen | $3,525,366 | 2,102 | $1,677 | $109,145,316 | -42.1 | 5 | Warner Bros. |