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| 1 | Ratatouille | $47,027,395 | 3,940 | $11,936 | $47,027,395 | -- | 1 | Buena Vista |
| 2 | Live Free or Die Hard | $33,369,559 | 3,408 | $9,792 | $48,398,130 | -- | 1 | Fox |
| 3 | Evan Almighty | $15,143,945 | 3,636 | $4,165 | $60,679,545 | -51.5 | 2 | Universal |
| 4 | 1408 | $10,662,804 | 2,733 | $3,902 | $40,442,058 | -48.3 | 2 | MGM |
| 5 | Fantastic Four: Rise of the SS | $9,143,876 | 3,424 | $2,671 | $114,944,684 | -54.3 | 3 | Fox |
| 6 | Knocked Up | $7,302,225 | 2,686 | $2,719 | $122,291,755 | -33.5 | 5 | Universal |
| 7 | Ocean's Thirteen | $6,085,959 | 2,903 | $2,096 | $102,120,537 | -46.7 | 4 | Warner Bros. |
| 8 | Pirates of the Caribbean: AWE | $4,960,368 | 2,162 | $2,294 | $295,703,075 | -31.1 | 6 | Buena Vista |
| 9 | Sicko | $4,501,712 | 441 | $10,208 | $4,616,786 | -- | 2 | Lionsgate |
| 10 | Evening | $3,501,971 | 977 | $3,584 | $3,501,971 | -- | 1 | Focus |