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| 1 | Talladega Nights | $47,042,215 | 3,803 | $12,370 | $47,042,215 | -- | 1 | Sony |
| 2 | Barnyard | $15,820,864 | 3,311 | $4,778 | $15,820,864 | -- | 1 | Paramount |
| 3 | Pirates of the Caribbean: Dead Man's Chest | $11,001,686 | 3,436 | $3,202 | $379,699,644 | -46.6 | 5 | Buena Vista |
| 4 | Miami Vice | $10,227,880 | 3,026 | $3,380 | $46,284,665 | -60.2 | 2 | Universal |
| 5 | The Descent | $8,911,330 | 2,095 | $4,254 | $8,911,330 | -- | 1 | Lionsgate |
| 6 | John Tucker Must Die | $6,150,596 | 2,566 | $2,397 | $28,723,356 | -56.9 | 2 | Fox |
| 7 | Monster House | $6,058,649 | 3,029 | $2,000 | $57,010,414 | -48.1 | 3 | Sony |
| 8 | The Ant Bully | $3,892,443 | 3,050 | $1,276 | $18,152,994 | -53.8 | 2 | Warner Bros. |
| 9 | You, Me, and Dupree | $3,643,430 | 2,263 | $1,610 | $66,822,635 | -48.7 | 4 | Universal |
| 10 | The Night Listener | $3,554,134 | 2,600 | $Miramax | $11 | 1 | 3,554,134 | The Devil Wears Prada |