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| 1 | Pirates of the Caribbean: Dead Man's Chest | $35,215,201 | 4,133 | $8,520 | $321,899,233 | -43.5 | 3 | Buena Vista |
| 2 | Monster House | $22,217,226 | 3,553 | $6,253 | $22,217,226 | -- | 1 | Sony |
| 3 | Lady in the Water | $18,044,396 | 3,235 | $5,578 | $18,044,396 | -- | 1 | Warner Bros. |
| 4 | You, Me, and Dupree | $12,767,590 | 3,137 | $4,070 | $45,299,080 | -40.7 | 2 | Universal |
| 5 | Little Man | $11,025,108 | 2,533 | $4,353 | $40,636,230 | -49.0 | 2 | Sony |
| 6 | Clerks II | $10,061,132 | 2,150 | $4,680 | $10,061,132 | -- | 1 | MGM |
| 7 | My Super Ex-Girlfriend | $8,603,460 | 2,702 | $3,184 | $8,603,460 | -- | 1 | Fox |
| 8 | Superman Returns | $7,375,213 | 2,826 | $2,610 | $178,342,711 | -40.0 | 4 | Warner Bros. |
| 9 | The Devil Wears Prada | $7,361,991 | 2,248 | $3,275 | $97,508,460 | -29.1 | 4 | Fox |
| 10 | Cars | $4,947,198 | 2,410 | $2,053 | $229,485,636 | -36.9 | 7 | Buena Vista |